The Lamming Laboratory at the University of Wisconsin-Madison
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Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.
Postdoctoral, Ph.D. students, M.D. students and undergraduates interested in pursuing research in the Lamming lab should contact Dr. Lamming directly at dlamming@medicine.wisc.edu.
Terrific Department of Medicine Research, and congratulations to Dr. Yang Yeh and Bailey Knopf for winning poster awards and Dr. Mariah Calubag for receiving the DOM Outstanding Graduate Student Award!
Three amazing award winners from the Lamming Lab at the 7th Annual Midwest Aging Consortium Meeting! Congratulations to all the winners and all participants! @baileyknopf.bsky.social Yang Yeh and Amirah Nieves Medina!
Please enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice" advanced.onlinelibrary.wiley.com/doi/10.1002/…
With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.
Pleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"
Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!
We are excited to share our first WiSLiM manuscript! With the help of @lamminglab.bsky.social and Dr. Cholsoon Jang, we attempt to challenge the dogmatic approach to post-bariatric surgery diet with some surprising results… @wiscsurgery.bsky.social @uwhealth.bsky.social
We have a thesis defense to celebrate today, but first – we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti…
Our most recent work by graduate student @mariahcalubag – demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!
"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41…
I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! onlinelibrary.wiley.com/doi/10.1111/…
Pleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv – "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" www.biorxiv.org/content/10.1…
Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.www.legacy.com/us/obituarie…
Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab! @natcomms.nature.com www.nature.com/articles/s41…
It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!
Congratulations to the recipients of the DOM Trainee Outstanding Research Awards! These awards recognize significant research contributions made during residency and fellowship training.
— University of Wisconsin Department of Medicine (@uw_medicine) July 18, 2025
With the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below. pic.twitter.com/oYfNq2hrkz
Glad this paper is finally out! Here first author @iCCup_Spec shows the power of protein and isoleucine restriction as late-life interventions, showing many positive benefits to health as well as positive and perhaps even rejuvenating benefits at the molecular level. https://t.co/OQVPtsfcHY
A slightly tardy but huge congratulations to lab graduate student @baileyknopf who won the UW Institute on Aging New Investigator Award for Biological/Biomedical Research! pic.twitter.com/k1H2soHglk
Proud to announce former grad student @pak_heidi's publication, "Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions" – or alternatively "Why don't we understand CR after ~100 years of study?" https://t.co/6JoPvLSJ6S
Pleased to announce the publication of @RejiBabygirija's long-awaited paper, "Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease" – also reverses metabolic deficits and improves cognition https://t.co/1KEKz8Sjdt
Arise, Dr. Michaela of house Trautman, a knight of the Lamming Lab! We are proud of you @michaelamRD and glad your family could join us on this momentous day! pic.twitter.com/yxgEg8JbRu
Our paper describing two new summary statistics, FAMY and GRAIL, enabling the quantification of healthspan in mice, is now out in Geroscience! https://t.co/ozP3eLgDKM This is a refined version ready to be used in your work (Those w/o journal access see https://t.co/FJXFcOOBp0). https://t.co/1k5qbWzBmG
Congratulations to Yang Yeh, PhD, research associate, Endocrinology, Diabetes and Metabolism on receiving a Wisconsin Initiative for Science Literacy (WISL) Award for Communicating Postdoctoral Research to the Public. pic.twitter.com/lkJtlTuTIM
— University of Wisconsin Department of Medicine (@uw_medicine) March 26, 2024
Congratulations to Dr. Dudley Lamming (@LammingLab) on being named the next Department of Medicine Vice Chair for Biomedical Research!
— University of Wisconsin Department of Medicine (@uw_medicine) March 18, 2024
Yesterday was not just our annual lab retreat (held jointly with @JudithSimcox lab this year), but the Lamming Decennial & Simcox Quinquennial Celebration! It is so hard to believe 10 years have gone by since that frigid polar vortex day I arrived at UW-Madison to open my lab.
